Objective: The aim of this study was to investigate the friction resistance of full ceramic self-ligating bracket (Damon Clear) and to compare it with other types of ceramic brackets using different types of wires. Materials and Methods: 63 ceramic brackets of the maxillary right canine with 0.022 x 0.028 inch slot were divided into 3 groups: (1) Damon Clear brackets, (2) Inspire ICE brackets, (3) Clarity brackets. Each group was subdivided into 3 subgroups by the combination with 0.017 x 0.025-inch of the following materials: (A) Beta-Titanium (TMA), (B) Stainless steel (SS), (C) Teflon coated – SS (TESS). A simulating canine retraction system was used in which the canine in the anterior segment could be moved distally to be in contact with the second premolar tooth. The test was performed using the ILLOYD universal testing machine and the data was analyzed using two-way ANOVA and Tuckey’s post-hoc test.Results: The results showed significant differences in the frictional resistance between the brackets P= 0.006, archwires P< 0.001 and their combinations P= 0.045, where Damon Clear bracket showed the statistically significantly highest mean friction force while there was no statistically significant difference between Clarity and ICE brackets; both showed the lowest mean friction force.Conclusion: Damon Clear brackets showed the highest frictional resistance among the brackets and TMA archwire showed the highest frictional resistance among the wires, However, Clarity brackets showed the least frictional forces among the brackets and TESS archwire showed the least frictional resistance among the wires and the combination of either Clarity or Inspire ICE brackets with 0.017 x 0.025-inch TESS wires produced the statistically significant lowest frictional forces.