Objectives: To perform a systematic review to quantify the amount of soft tissue changes measured in cephalograms in adults orthodontics patients who have Class III malocclusion and undergone camouflage treatment.Materials and methods:Search Strategy: Electronic databases were searched up to March 2015 in (CENTRALCochrane register of controlled trials, PubMed, Embase, DopPHER). Grey literature was also searched electronically through Google Scholar. Hand searching was done in high impact factor journals in the field (AJODO, CJO, The Angle Orthodontist). Email alert for PubMed and google scholar were set and monitored until March 2015. Citations of all the included studies were also checked manually for relevance. Language was restricted to English.Selection criteria: The following criteria were met for study selection: a controlled human trial on a group of adult patients receiving orthodontic extraction of lower viii incisor compared to a group of extraction lower first premolars in Class III malocclusion. Studies that involved growing patients, orthopedic fixed or removable functional appliances or combined orthodontic and surgical treatment were excluded. Studies with no soft measurements on cephalometric head film were not taken before and after treatment were also excluded.Results: Three articles were eligible for the descriptive analysis and quantitative analysis. Quality assessment of the included articles showed low to moderate quality. Meta-analysis using the random effect model to evaluate the mean difference (MD) with level of significance set at P≤ 0.05 was performed for cephalometric soft tissue measurments : Labrale inferioris to E-line , Labrale superioris to E-line , overjet, labrale inferioris to\holdway line as linear cephalometric measurments. While interincisal angle, ANB angle lower incisor \mandibular plane, lower incisor \ NB and angle of convexity as angular cephalometric measurementsConclusion:•Upper lip showed significant retrusion in relation to E- line in premolars extraction than incisor extraction group.•Lower lip showed significant retrusion in relation to E- line in premolars extraction than incisor extraction group.•ANB angle showed no or little changes in both groups.•Interincisal angle showed significance increase after extraction for both groups.•Lower incisor showed significant retraction in relation to mandibular plane for both groups, that retraction was more in lower premolars extraction group.