Orthodontic treatment always aims to achieve its esthetic and functional goals with the maximum benefits and the least side effects. Orthodontic treatment usually requires a long duration of about 2-3 years, which poses high risks of caries, external root resorption, and decreased patient compliance. Consequently, the need to accelerate the rate of orthodontic tooth movement and to shorten the treatment duration becomes a necessary goal. For several decades, surgical corticotomy was proven to be an effective and safe method to accelerate OTM. Recently, low level-Laser therapy (LLLT) has been introduced as a conservative tool to shorten the treatment duration. The aim of the present study was to compare, a standard efficient but invasive technique like surgical corticotomy in accelerating OTM to another modality such as LLLT which is non-invasive and easily accepted by the patient.The study design was a randomized split mouth design to compare, clinically and radiographically, between the two interventions (Laser and Corticotomy) by assessing the rate of maxillary canine retraction achieved in 4 months. Secondary outcomes were to evaluate 1st maxillary molar anchorage loss, changes in tipping ant torque values of maxillary canine and 1st molar. In addition, the impact of both interventions on periodontal health was assessed. The present study was carried on 20 patients, 19 females and 1 male. All patients required maxillary 1st premolar extraction and subsequent maxillary canine retraction. After placement of upper and lower fixed appliances and completion of leveling and alignment stage, miniscrews were used for establishment of maxillary 1st molar anchorage. Prior to 1st premolar extraction, CBCT imaging was performed to assess the pre-intervention canine and molar position, tipping and torque. On the day of maxillary premolars extraction, both interventions were randomly applied (corticotomy and LLLT) together with the start of canine retraction. The corticotomy procedure consisted of submarginal full mucoperiosteal buccal flap elevation extending from the mid surface of the maxillary lateral incisor to the mid surface of the extraction socket. This was followed by cortical perforations done around the root of maxillary canine. Low level Laser therapy was applied on the buccal aspect of maxillary canine, delivering a total energy of 29J/cm2. Protocol of Laser administration proceeded as follows: At the day of extraction, then once a week for the 1st month of canine retraction, followed by one application every 2 weeks for the next 3 months. Assessment of the rate of canine retraction and 1st molar anchorage loss was carried out via series of dental models at each Laser application session. CBCT images were used to evaluate the total distance traveled by the maxillary canine, 1st molar anchorage loss, tipping and torque of both, maxillary canine and 1st molar after 4 months of canine retraction on both sides. No statistical significant difference was found between both interventions as regards the total distance traveled by the maxillary canine at the end of the 4 month study. Similarly, the rate of canine retraction recorded at each 2 weeks follow up period showed statistical non-significant difference on both intervention sides. Moreover, no difference was found in amount of molar anchorage loss or in any CBCT variables assessing tipping and torque of maxillary canine and 1st molar. Periodontal assessment showed statistical non-significant difference regarding the periodontal probing depth, gingival margin and gingival and plaque indices.