A collaborative project was confirmed between Orthodontic department, Faculty of Oral and Dental Medicine, Cairo University and the Ministry of Health to investigate the birth incidence of cleft lip and/or palate patients, from the 1st of January to the 31st of December 2013. This study represented a part of the project and aimed with the incidence in Al-Monufia, Qena and Al-Sharkia governorates. To ensure precise data collection, primary health care facilities, main governmental hospitals of the Ministry of Health, University hospitals, main health offices and Smile Train treatment centers were selected, as reliable sources of gathering data in the assigned governorates. All newly born babies included in the study were born to Egyptian parents. Still births and abortuses affected by clefts were excluded. In this study, Shapira′s classification was selected due to its reliability, efficiency and simplicity since it was found to be easier for the health care staff to apply. Diagnostic sheets were distributed among the selected areas, containing full data about each cleft case. Cases were diagnosed and recorded in the diagrammatic sheet by the health care staff and was double rechecked by the candidate.Parents were instructed on how to feed and to take care of their babies and they were referred for follow up with the cleft lip and/or palate team at the Orthodontic Department, Cairo University for pre-surgical orthopedic correction if needed, as represented in (naso-alveolar molding and feeding plates), then they were referred for the surgery needed at theproper time following the planned cleft lip and/or palate management protocol (Appendix III).The collected data was statistically analyzed and the following conclusions could be drawn:1.The mean incidence value of Cleft Lip and/or Palate in the three Egyptian studied governorates was 0.24/1000.The incidence value varied between the governorates where the highest incidence was 0.29 in Qena governorate, followed by Al-Monufia with a incidence of 0.27 and finally Al-Sharkia governorate with a incidence of 0.19/1000.2.Cleft lip and/or palate defects were dominant in males than females, but this sex difference was statistically insignificant in the three studied governorates.3.Regarding to the cleft types: the most prevalent type was the cleft lip (55.2% of the total cleft defects) with a superior value in Qena governorate ( 43.8%) followed by the cleft lip and palate (23% of the total cleft defects) with highest percentage in Al-Monufia governorate (23%).