The aim of this study was to evaluate and compare the effectiveness of resin infiltration and acid-microabrasion in treatment of post-orthodontic white spot lesions. This was a split-mouth, randomized controlled clinical trial. Ninety post-orthodontic white spot lesions (scores 1 and 2 on the ICDAS II scale) in 36 quadrant were divided into two groups. Ninety post-orthodontic white spot lesions (scores 1 and 2 on the ICDAS II scale) in 36 quadrant were divided into two groups.Visual assessment of white spot lesions was done using International Caries Detection and Assessment System (ICDAS-II) for scoring dental caries.The scoring criteria according to the ICDAS-II system for Coronal Smooth Surface Caries are graded from 0 to 6. Patient satisfaction score was recorded according to patient's own selection for each quadrant before, after intervention, after 3 months and after 6 months follow up.Conclusions: Both Icon and Opalustre improved esthetics of demineralized lesions. Icon resin infiltration improves the esthetic appearance of demineralized teeth significantly more than acid microabrasion immediately after application. Esthetic outcomes of icon resin infiltration and opalustre show adequate stability for 6 months.