Introduction: The aim of this study was to investigate the association between GHR gene mutation in Exon 10 and Craniofacial morphology in Egyptian subjects The study was conducted to investigate the association between SNPs; C422F, P477T, I526L and P561T with craniofacial morphology.. Materials and Methods: The present study was conducted to investigate the association between SNPs; C422F, P477T, I526L and P561T with craniofacial morphology. Thirty eight adults were recruited from the department of Orthodontics, Faculty of Oral and Dental Medicine Cairo University. The patients were examined clinically and based on their facial profile cephalogram was performed. All participants were Egyptian with full permanent dentition and under active orthodontic treatment. Exclusion criteria entail any developmental anomalies as clefts or syndromes involving craniofacial disfigurements and previous history of orthognathic surgery and or growth modification therapy.After completion of the cephalograms; cephalometric landmarks were located. Manual tracing of the cephalometry was performed including 6 angular and 5 linear measurements. Two ml venous blood was collected from each patient for DNA extraction. Results: Cephalometric analysis showed that 20 patients were skeletal class I while diagnosis of skeletal class III was confirmed in 18 subjects. Genetic analysis showed that in the SNP C422F (G/T), the homozygous genotype (GG) comprised 78.9% of the study sample while the heterozygous genotype (GT) comprised 21.1%. In the SNP P561T (C/A), the homozygous genotype (CC) comprised 76.3% while the mutant homozygous genotype (AA) comprised 2.6% and the heterozygous genotype (CA) comprised 21.1% of the population sample. As regard SNP P477T (C/A), the homozygous wild genotype (CC) comprised 92.1% of the study sample and the heterozygous genotype (CA) comprised 7.9%. On the other hand, in the SNP I526L (A/C) the homozygous wild genotype (AA) comprised 44.7% and the homozygous mutant genotype (CC) comprised 18.5% and heterozygous genotype (AC) comprised 36.8% of the population under study. The genotype distributions of the four SNPs C422F (G/T), P561T (C/A), P477T (C/A) and I526L, (A/C) among individuals were in Hardy – Weinberg equilibrium. Statistical analysis revealed insignificant association between genotypes of different SNPs and mandibular protrusion. Moreover, the association between I526L, P561T, C422F SNPs genotypes and skeletal classes failed to reach significant levels. On the other hand the association between P477T and skeletal classes was statistically significant. No statistically significant differences were recorded between with different genotypes of the SNP C22F and different measurements except for GG and GT with AoBo, ANB and AD’. Although, no statistically significant differences were detected between cases with CA and CC genotypes of the SNP P561T, both showed statistically significantly higher mean Cd-Go than the case with AA genotype. Cases with CA genotype of the SNP P561T showed a statistically significantly higher mean PP/SN° than those with genotypes AA and CC. Conclusion: The genotype of SNP C422F showed significant association of GG and GT with antroposterior of GG and GT with anteroposterior jaw relation (AoBo, ANB and AD’).