BackgroundFace mask treatment on growing patient produce skeletal and dental effect and different studies stated that face mask produce improving effect on soft tissue profile that following under skeletal profile changes and other studies were stated that no significant effect of face mask on soft tissue so no evidence found on literature on effect of facemask on soft tissue profile with or without expansion used with face mask for maxillary protraction treatment.ObjectiveMain objective in this review to evaluate evidence of effect of Face mask in soft tissue profile in treatment of skeletal class lll growing patients with or without maxillary expansion.Search StrategyFollowing key words were used in different electronic database searchFacemask-skeletal class - maxillary expansion – maxillary protractionsoft tissue profile-reverse pull head gear detailed search strategy were performed in following electronic database (Pumped-Google scholar-Cochrane electronic data bases) to collect all eligible studies in English language that matching inclusion criteria of this review.Selection criteriaThe following criteria were met inclusion criteria for study selection: controlled or non controlled clinical trials on growing patients receiving orthopedic face mask treatment with or without maxillary expansion or retrospective studies with soft tissue profile measurements before and after treatment. Studies that were involved adult patient or fixed appliance combined with face mask treatment or surgical treatment or cleft patient or any other dento facial defects were excluded also StudiesResultsFourteen studies were obtained after filtration and were eligible for the descriptive analysis and 3 were eligible for the quantitative analysis.Quality assessment of the included articles showed moderate to high quality. Meta-analysis were done to evaluate effect of face mask on soft tissue using the fixed and random effect model to evaluate the mean difference (MD) with level of significance set at P0.05 was performed.Meta analysis includes three studies two studies are randomized clinical trials studies and one study is controlled clinical trial with moderate quality.Meta analysis was done in three measurements as a following:Labrale superiusLabrale inferiusNaso labial angle.The result showed significant forward movement of upper lip were obtained regarding the, no significant difference was found regarding Naso labial angle and lower lip position. these results are based on three studies of moderate to high quality studies are randomized clinical trial,Kiliçolu et al (1998)1 studies are randomized clinical trials while ar etal (2011)2 and Yagci et al.(2010)3 controlled clinical trial.