Introduction: The aim of this clinical study was to compare the use of two different force magnitudes (100 gm and 200 gm) with indirect mini-screw implant anchorage, and evaluating the rate of canine movement, amount of molar anchorage loss, canine disto-buccal rotation and canine mesio-distal tipping. Methods: The sample consisted of 15 adult female patients (mean age, 19.4 years) requiring therapeutic extraction of the maxillary first premolars, with subsequent retraction of the maxillary canines. Nickel-titanium closing coil springs delivered a force of 100 g or 200 g were used to retract the canines after an alignment and stabilization period. The force delivered was measured using a push–pull force gauge. Maxillary cast measurements were made at the beginning of canine retraction (T0) and every 28 days for 84 days (T1, T2, T3) to assess canine retraction rates. Photocopies of pre-retraction and post-retraction maxillary casts were taken to measure molar anchorage loss and canine rotation. Pre-retraction and post-retraction panoramic radiographs were taken to measure canine tipping. Results: The amount of initial tooth movement (T0-T1) was not related to force magnitude. However, during (T1-T2) and (T2-T3) periods, significant increase in the amount and rate of tooth movement were found with 200 gm group than 100 gm group. Canine rotation, tipping and anchorage loss were significantly higher in 200 gm group than 100 gm group. Conclusion: Canine retraction proceeds at a faster rate in 200 gm group. Indirect mini-screw anchorage was not effective in preventing anchorage loss in both groups.