Since the discovery and characterization of multipotentmesenchymal stem cells (MSCs) from dental pulp. The osteogenic capacity of the MSC has been studied in vitro. Early work demonstrated that MSCs cultured on tissue culture in the presence of Dulbecco modified Eagle’s media (DMEM) supplemented with 10% Fetal bovine serum (FBS) and 50µg/ml of L-ascorbic acid 2-phosphate display changes in gene expression consistent with osteogenesis and mineralization of extracellular matrix. The pulp tissue contains stem/progenitor cells that potentially differentiate into osteoblasts in response to bone morphogenic proteinstype II (rh-BMP 2) while the control group without bone morphogenic proteins type II (rh-BMP 2) showed no osteoblastic differentiation. The two groups where stained with Alzrin red stain, the control group showed negative stain while the other group with bone morphogenic proteins type II (rh-BMP 2)showed positive stain demonstrating osteoblastic differentiation. This study concluded that dental pulp stem cells could be cultured and expanded for several passages without losing their specificity and maintaining their capacity to differentiate into hard tissue-like forming cells. Dental pulp stem cells induced to differentiate into osteoblast-like cells with morphogens like rh-BMP-2 may be a good potential for clinical use in cell therapy for orthodontics. Large no. of dental pulp stem cells could be isolated from single pulp tissue which could be further used in tissue engineering and orthodontics. Dental pulp stem cells demonstrated high proliferative rate and doubling time among other oral sources of stem cell which makes it one of the most recommended sources of stem cells to be used.