Objective: The aim of this study was to evaluate clinically and histologically Corticotomy Facilitated Orthodontics using Piezosurgery versus Rotary instruments. Materials and Methods: Ten healthy adult male mongrel dogs of comparable age with a complete set of permanent dentition with their weights averaged between 13 – 17kilograms were used. For every dog, mandibular second premolars retraction on each side was attempted after extracting third molars followed by corticotomy facilitated orthodontics with conventionalrotary surgical burs on the left side; and using ultrasonic Piezosurgery system on the right side of the same animal. Intraoral measurements of the rate of tooth movement were taken with a sliding caliper. Records were performed at the time of surgery (appliance delivery) and every one month for six months by one operator. Then dogs were divided into two groups based on the time of animal scarification; in Group 1 (G1) dogs were sacrificed after one month from initiation of tooth movement in order to evaluate the initial tissue reaction using Hematoxylin and Eosin (H & E) sections following both corticotomy techniques. Group 2 (G2) dogs were sacrificed after six months from initiation of tooth movement in order to evaluate the final tissue reaction using Hematoxylin and Eosin (H & E) sections and the rate of tooth movement following both corticotomy techniques. Results: The result of the current study showed statistically significantly higher mean amount of tooth retractionmovement for conventional rotary technique than Piezosurgery corticotomy technique after six months from tooth movement; confirmed by rapid alveolar bone remodeling and turn over. On the other hand, Piezosurgery corticotomy samples showed more bone matrix formation and better ossification than theconventional rotary corticotomy samples in all time intervals (Group 1& 2).Conclusions: Corticotomy is a valid technique that could be used to enhance the rate of tooth movement that was increased from (0.8-1.2 mm/month) using conventional orthodontic mechanics to (1.43 mm/month) using corticotomy facilitated orthodontics, compared to corticotomy technique using Piezosurgery (0.85mm/month). Corticotomy technique using Piezosurgery device showed better bone healing compared to corticotomy using conventional rotary instruments as confirmed by the histological findings.