The purpose of this research was to study the oral health condition including caries affection, gingival disease involvement and occlusal abnormalities among a group of Egyptian sickle cell anemia children in addition to evaluate the efficacy of the provided dental health education program. Sixty-two children aged from six to twelve years old having sickle cell anemia were included. Oral examination was done using DMFT, deft, gingival, plaque and simplified oral hygiene (OHI-S) indices, anteroposterior dento-alveolar relationships and facial profile in addition to assessment of radiographic bone changes. A specially designed dental health program was provided and follow up after one month was done. Results showed relatively high mean deft and OHI-S among included patients. A statistically significant decrease in mean OHI-S and mean Debris index component was noted (P-value < 0.001). Bone changes included thinning of cortical bone, bone rarefaction and widening of marrow spaces. Genotype affects the facial profile while residence affects high caries experience and oral hygiene. Severity of sickle cell disease affects dental diseases. Conclusion: Severity of sickle cell disease is directly related to severity of oro-dental condition.