Objectives: The aim of study to evaluate, in-vitro, the fracture resistance ofmilled titanium ceramic fixed partial dentures using two types of margin designs: [Shoulder finish line, Deep chamfer finish line] and two types of framework extensions [framework with both retainers extended to the end of finish line (metal collar) (metal margin), a framework with anterior retainer 1mm shorter than the finish line (collarless metal) (circumferential porcelain margin)].Materials and methods: Two specially designed stainless steel models were constructed with two different finish lines. A total number of twenty milled titanium ceramic fixed partial dentures replacing missing maxillary second premolars were constructed by Biodenta CAD/CAM software and divided into two equal groups (10 samples each) according to the type of finish line; GI: shoulder finish line and GII: deep chamfer finish line. Each group was further sub-divided into two equal sub-groups (5 samples each), according to the degree of extension of the margin of the metal frameworks; GA: framework with both retainers extended to the end of finish line (metal collar), and GB: framework with anterior retainer 1mm shorter than the finish line (collarless metal) (circumferential porcelain margin).The CAD/ CAM milled titanium FPDs were fabricated from Grade 5 titanium with the same standard dimensions as controlled by Biodenta CAD/CAM software. After titanium frameworks were fabricated, it was veneered by (ceramic 2 in 1). Total thickness of porcelain and metal was uniform of (1.5 mm). Ten impressions were made for each finish line design and the duplication of the metal models into Epoxy Resin models were done. Each FPD were cemented over its corresponding epoxy resin model using Rely X Unicem adhesive rein cement. The samples were tested for fracture resistance using Lloyd universal testing machine. The data were collected, tabulated and subjected to statistical analysis (P ≤ 0.05).Results: ANOVA showed that there was no statistically significant difference between mean fracture resistances of FPDs with shoulder finish line (1654.5 ± 213.7 N) and deep chamfer finish lines (1501.2 ± 212.4 N).FPDs with Metal margin showed statistically significantly higher mean fracture resistance (1707.2 ± 146.2 N) than FPDs with circumferential porcelain margin (1448.5 ± 212.7 N). The statistically significantly lowest mean fracture resistance was found with FPDs with (Deep chamfer finish line with circumferential porcelain margin) (1376.6 ± 205.5 N).Conclusions: 1.Changing the finish line design (shoulder finish line, deep chamfer finish line) had no effect on the fracture resistance values.2. Milled titanium FPDs with metal margins required a greater load on fracture than FPDs with circumferential porcelain margins.