Statement of problem: many clinicians are reluctant to use the cantilever design especially with the earlier all-ceramic materials.Purpose: The present study was designed to test yttrium-oxide partially stabilized zirconia all ceramic with the cantilever extension, and whether an added abutment would contribute to better results.Material and methods: Thirty FPDs were constructed to restore missing maxillary lateral incisor. The fixed partial dentures were divided according to the design into three groups. Each group was further subdivided into two equal subgroups according to the material of construction; yttrium partially-stabilized zirconia utilizing Cerec-Inlab system and metal ceramic. The bridges were cemented onto epoxy-resin models using adhesive resin cement and subjected to cyclic loading for ten thousand cycles, then to fracture load testing using universal testing machine to evaluate the fracture resistance. Data were collected, tabulated and statistically analyzed. The fractured surfaces of the specimens were examined using scanning electron microscope (SEM) for failure mode evaluation.Results: Bridge design and material of construction had a significant effect on the load to failure value (P-value < 0.001).The mean and standard deviation values of fracture resistance for all-ceramic FPDs were 359 ± 69.8 N, 487.8 ± 67.6 N and 686.3 ± 107.2 N for cantilever design (1 abutment), cantilever design (2 abutments) and fixed-fixed design respectively. The mean and standard deviation values of fracture resistance for metal-ceramic FPDs were 359.1 ± 107.9 N, 720.6 ± 74.7 N and 1021.3 ± 66.7 N for cantilever design (1 abutment), cantilever design (2 abutments) and fixed-fixed design respectively. Two-way ANOVA statistical analysis showed that the interaction between the two variables had a statistically significant effect on mean fracture resistance (P-value < 0.001)Conclusions: All-ceramic Y-TZP cantilever bridge restoring the maxillary lateral incisor supported solely by the canine could withstand successfully the maximum loads to which the anterior area is subjected. Adding an extra abutment would significantly increase the fracture resistance.