Purpose: The aim of this study was to investigate and compare micro-strains generated around dental implant under cyclic loading while using all ceramic “Zirconia” and all resin “Thermoplastic BIO-XS” superstructures and their corresponding veneering materials.Materials and Methods: Dental implant was embedded vertically “0 tilt” in an epoxy resin model. One zirconia abutment was attached to the assembly. 10 identical crowns were constructed representing lower second premolar. Crowns were classified into 2 groups. Group 1 “all ceramic” and group 2 “all resin” with 5 crowns in each group. 5 microstrain gauges were attached to the model buccally, lingually, mesially, distally and apically. Using the universal testing machine, vertical cyclic loading of 200 N was applied on the buccal cusp of each crown for the total of 100 cycles. Mean micro-strains generated were statistically analyzed in 3 different comparisons; Comparison 1 between the 2 different groups under investigation, comparison 2 between cervical surface including “buccal, lingual, mesial and distal surfaces” and apical surface within the individual group, and comparison 3 between all different surfaces within the individual group.Results: There was no statistically significant difference between meanmicrostrain values induced in the two materials in the buccal, lingual, mesial, distal and apical surfaces.Conclusions: The superstructure material of implant supported fixed prosthesis - either all ceramic or thermoplastic resin- had no influence on the micro strains generated in implant and surrounding bone. The protective role of resin for the implant-bone interface could not be demonstrated.