Purpose: The aim of this article was to evaluate the speech ineligibility and the interference with speech in patients wearing maxillary removable partial dentures with two different major connector designs. Materials and Methods: Ten completely dentulous subjects and ten patients with Kennedy class-I partially edentulous maxilla were enrolled in the present study. Two skeleton RPDs with two different major connector designs were constructed for each patient. RPD with antro- posterior (AP) and mid palatal (MP) major connector deigns. Subjective analysis of speech intelligibility, Objective analysis of speech, correlation of subjective and objective speech analysis as well as comparison of speech ineligibility of different sounds in patients wearing RPDs and the normal subjects enrolled in the present study. Evaluation was carried-out before RPD insertion visit, at RPD insertion, one month and three months after. Results: Both RPD designs had affected the speech intelligibility of the studied sounds. However, the interference with speech was least with the AP design than MP design especially after long period of insertion. The speech intelligibility was improved after RPD fitting especially for sounds /k/ /g//r/. After both denture fitting(more improved with AP design. /s/ /∫/ /j/ sounds showed little improvement in intelligibility score after both denture insertion. Conclusions Within the limitations of the present study, it may be concluded that the AP major connector is recommended from a phonetic viewpoint. — The results of speech intelligibility suggested that using the AP major connector has the least interference with phonetic function.