This study was done to evaluate the linear and angular deviation between the virtual and the actual implant positions for implants inserted using single drill versus full sequence tissue-supported computer aided surgical guide. The sample of this study consisted of fifteen patients randomly selected from outpatient clinic of prosthodontic department, faculty of oral and dental medicine, Cairo University. All patients were completely edentulous, cooperative and with adequate interarch space. Preoperative CBCT was taken while the patients wearing the radiographic stent with three equally distributed radiographic markers. The Preoperative CBCT was used for dental implants planning and formation of the surgical stent. During the surgery one side of the dental arch received two implants with full sequence guided approach, while the other side received another two implants with pilot drill guided approach. Through one week after surgery, the second CBCT was taken for all patients while the patients wearing the same preoperative radiographic stent. For measurement of deviation amount between the virtually planned and actually placed implants in both the pilot drill guided and full sequence drilling guided protocol, superimposition of the preoperative planning and postoperative CBCT by the aid of Mimics10.01® software. The deviation between the planned and placed implants was measured in the mesio-distal plane and bucco-lingual plane. Four deviation parameters were defined on each plane (global linear, lateral, depth, and angular). The four parameters were measured for the coronal and apical center except for the angular deviation. After four months patients were delivered maxillary and mandibular screw retained prosthesis. In this study it was found that there is no statistically significant difference in linear deviation between implants placed by the single drill guided surgical protocol and that are inserted by the full sequence drilling guided surgical protocol. Only there was a statistically significant difference in the angular deviation in the bucco-lingual direction, showing slight more deviation for implants placed with the single drill guided surgical protocol. However, this deviation is somewhat clinically irrelevant.