Aim: The present in vivo study aimed to find the correlation between bone density of implant placement sites and primary stability of implants using a computer guided implant system.Patients and methods: Fourteen patients with completely edentulous maxillary and mandibular arches wererecruited. Each arch received preplanned four implants based on data obtained from a preoperative cone beam computerized tomography (CBCT). Drilling for the implant was done with the surgical stent secured in its place. After preparation of the osteotomy sites, the implants were threaded with the implant mount using a ratchet. Using the “Measure Density in Eclipse” (feature of the Mimics 10.01 Software) the bone density in the implant placement sites was recorded ,then categorized according to Misch 2008 classification into the four bone types (D1,D2,D3,D4).Clinical evaluation was carried out for implant stability using resonance frequency analysis immediately after implant installation using the Osstell ISQ device. Each Implant’s stability was measured in the bucco-lingual and the mesio-distal direction using the Osstell’s Smartpeg tool screwed to the implant.Results: A non-significant difference between the primary stability of implants in maxilla and mandible despite the significant difference found between the bone densities of both arches.Conclusion: There is a weak positive relation between the bone densities of implant osteotomy sites (HU) and the primary stability of the implants (ISQ).