This study included 40 consecutive patients with chronic HCV infection intended to receive antiviral treatment (pegylated interferon and ribavirin). The patients of this study were grouped according to histopathological examination of liver biopsy into 2 groups: group F2 include 25 patients and group F3 include 15 patients, 20 patients (50%) of them with history of schistosomiasis and the other 20 patients (50%) with no history of schistosomiasis. In this study, the Fibroscan showed significant positive correlation with the age, AST, ALT, liver biopsy. However, Fibroscan showed significant negative correlation with platelet and albumin. The study revealed that, 16 patients (64%) out of (25) had F2 in liver biopsy and Fibroscan with sensitivity 64% and PPV 88.9%. Both Fibroscan and liver biopsy showed F3 liver fibrosis in 7 patients (46.7%) out of (15) with sensitivity of 46.7% and PPV 58.3%.