This study was performed on 57 patients having liver cirrhosis with 63 focal hepatic lesions detected by ultrasound and proved histopathologically to be HCC by ultrasound guided biopsy and/or fine needle aspiration cytology. They were 50 males and 7 females their ages ranged between 37 and 75 years old. Patients were classified randomly into two groups, Group A was formed of 32 patients with 37 focal lesions where they received RFA. Group B encountered 25 patients with 26 focal lesions and they received PAI. As regard the outcome of therapy in group A, complete ablation was achieved in 14/18 (78%) lesions ≤ 3 cm. For lesions ranging between 3.1-4 cm, complete ablation occurred in 7/11 (64%) lesions and lastly 4/6 lesions ranging between 4.1-5 cm were completely ablated. There was no size range with more favorable outcome. In group B, complete ablation for lesions ≤ 3 cm occurred in100% of cases while in lesions ranging between 3.1-4 cm it was achieved in 8/9 (89%) of the lesions. For lesions ranging between 4.1-5 cm complete ablation was achieved in 5/7 (71.4%) lesions. Again here there was no size range with more favorable outcome. On comparing the outcome of both techniques the overall success in group A was 71.4% while in group B it was 88.4% with no significant statistical difference (P value= 0.13).As regard the number of sessions in each group, the mean number of sessions in group A was 2.2 while in-group B it was 2.19 with P value 0.72.As regard complications, major complications occurred in group A only in 4 patients. One patient developed an attack of haematemesis another one developed second degree burn at the site of grounding pads, the third developed pneumothorax and the fourth developed malignant pleural effusion. Minor complications occurred in both groups but it was more evident in group B. Pain occurred in 44% of cases in group A and in 84% of cases in group B. Fever was reported in 6 % of cases in group A and in 56% of cases in group B. Lastly ascites occurred in 1 case (3.1%) in group A and 4 cases (16%) in group B.