Statement of problem: IPS Empress 2 is a brittle material. Recently milled zirconia restorations have become widely used in dental applications, but some questions exist about their marginal accuracy and fracture resistance when cemented on milled zirconia implant abutments. Material and Methods: a total number of 15 titanium implants was attached to their corresponding copy milled zirconia abutments from titanium abutment (direct spectra system) that will be loaded with fully anatomical upper premolar shape fabricated of different suprastructure crowns which are divided into 3 groups; Group A: n=5 CAD/CAM Zirconia crowns; Group B: n=5 IPS Empress 2 crowns and Group C: n=5 Porcelain Fused to Metal as control group. The margins of suprastructure crowns were tested using stereomicroscope before and after cementation. Rely X Unicem 3M was used for cementation of suprastucture crowns after surface treatment protocols for each group. Fracture resistance was tested using Insteron Universal testing machine parallel to the long axis. Results: ANOVA test showed that there was a statistically significant differences between the three groups (P-value <0.001). The mean and standard deviation values of a gap distance before and after were (0.048 ± 0.001, 0.066 ± 0.001) micron with Empress2, (0.026± 0.002, 0.042 ± 0.002) micron with PFM and (0.033 ± 0.002, 0.050 ± 0.002) micron with Zirconia. The mean and standard deviation values for fracture resistance were 842.9± 173.2 N with IPS Empress2, 890.7 ± 115.3 N with PFM and 956.7 ± 145.9 N with Zirconia. Conclusion:CAD/CAM milled zirconia suprastructure crowns have more marginal accuracy and fracture resistance than Press on IPS Empress 2 when be cemented with Rely x dual cure cement.