Hyperhidrosis is characterized by sweating in excess of the physiologic amount necessary to maintain thermal homeostasis. Hyperhidrosis is a common and extremely distressing condition with a prevalence of 2.8% of the population. For those affected, this condition is extremely debilitating with significant impairment in activities of daily living, social interaction, and occupational activities. Hyperhidrosis is divided into primary or idiopathic hyperhidrosis and secondary due to a variety of causes. This classification is further categorized as generalized or focal with respect to its clinical presentation. Primary or idiopathic hyperhidrosis is usually focal and limited to the axillae, palms and soles, and face. Secondary hyperhidrosis can be focal or generalized, affecting the entire body. Treatment strategies for hyperhidrosis include topical, oral, surgical, and nonsurgical treatments. These treatment modalities differ with respect to their therapeutic efficacy, duration of effect, side effects, as well as cost of therapy.