Aim of study: evaluate the effect of bioactive glass and casein phosphopeptide- amorphous calcium phosphate (CPP-ACP) on repairing the color of enamel white spot lesions after 1, 30 and 60 days. Material and method: Thirty non carious extracted human premolar were selected in this study. Teeth were randomly divided into four main groups by coloring the surface of each tooth root with a different varnish color. G1: control positive, G2: control negative, G3: bioactive glass, G4: CCP-ACP. All the teeth were immersed in demineralizing solution for 72 hours. Then each group were further subdivided into three subgroups according to the aging time; (T1: 1 day, T2: 3o days, T3: 60 days). All samples were tested by spectrophotometer to measure the color differences (∆E) when compared to sound and demineralized enamel. The results were calculated and statistically analyzed using One way ANOVA followed by pair-wise Tukey’s post-hoc tests. Results: both bioactive glass and CPP-ACP statistically significant to improve the color of demineralized enamel after one and 30 days. After 60 days bioactive glass showed the lowest statistical significant mean ∆E. The effect of the time storage was statistically non-significantly for both bioactive glass and CPP-ACP, while it was significant for the negative control group. While it showed at 60 days the lowest statistical significant mean ∆E. Conclusion: Bioactive glass and CCP-ACP are good remineralizing agents that cause repair the color of demineralized enamel, Time didn't decrease the effect of bioactive glass while its negatively affecting the color repair capacity of CCP-ACP.