The use of prophylactic Antibiotics in dental implants is controversial; this study addresses the question “Should prophylactic Antibiotics be administered prior to the dental implant surgery, in normal patients?” It is generally advised to minimize the use of Antibiotics to avoid the development of Antibiotic resistant bacterial strains and to decrease the incidents of adverse effects. A sample of 12 healthy patients was selected to be candidates fulfilling the selection criteria of this study to become subjected to the designed course of treatment. The average range of age was from twenty five to forty years of age, all of them were indicated for teeth extraction, without the presence of peri-apical infection. All the patients fulfilled the research criteria. Only patients indicated for extraction of teeth without periapical pathosis were included in the selection. All cases were clinically examined, and radiographically assessed with periapical and panoramic radiographs, before being subjected to extraction followed by immediate dental implant placement. All surgical procedures were carried out under complete standard aseptic conditions and techniques. Atraumatic extraction of the teeth was carried out followed by instant implant insertion – with delayed loading – using Sargon Implant System. Procedures were carried out according to standard procedures of Implant insertion according to manufacturer’s directions and under strict aseptic condition. The surgical site was closed by sutures. The patients were randomly divided into two equal groups of six patients each, whereby both groups received the same treatment – except for the antibiotic therapy. Accordingly, the patients of one group were receiving true antibiotic regimen, while the patients of the second group received placebo treatment. Post operative evaluation including clinical and radiographic assessment for both groups was carried out over the periods of one, three and six months, and the results were plotted for analysis.It might be sensible to suggest a routine use of one dose of 2 g of prophylactic amoxicillin just before placing dental implants. It remains unclear whether an adjunctive use of postoperative antibiotics is beneficial, and which is the most effective antibiotic. In conclusion, it appears that antibiotic prophylaxis for routine dental implant surgery offers some advantage for the patient. The scarcity of sample size was attributed to the high cost per sample studied, difficulties of follow up and commitment level of patients. Accordingly, it is recommended to follow with more studies with expanded sample size. The Antibiotic regimen followed in this study was unified – providing consistency to all sample members – needs to be assessed in comparison to different regimens in terms of dose and type used.