Aim: This study was to evaluate the clinical and radiographic efficacy of photo – activated oral disinfection and triple antibiotic mix in management of primary molars.Materials and Methods: All children were selected randomly from the outpatient clinic of Pediatric Dentistry Department, Faculty of Oral and Dental Medicine, Cairo University. Sixty four non-vital primary molars were involved and divided into four different groups. Group I using photoactivated oral disinfection and premixed calcium hydroxide & iodoform paste. Group II using triple antibiotic mix. Group III using photoactivated oral disinfection and triple antibiotic mix. While, group IV using premixed calcium hydroxide and iodoform paste. Single visit pulpectomy was done for all groups.Results: Clinical success rate for group I and IV was 100% at 12 monthsfollow up period. All radiographs were evaluated blindly by the aid ofthree different evaluators at different times. The radiographic evaluationof group I at 12 months follow up period showed that 100% success ratefor resolution of furcation and radicular radiolucency and this wasevidenced by the increase in the mean bone density at the furcation area.The radiographic evaluation of group III at 12 months follow up periodshowed 93.3% and 100% success rate for furcation and radicularradiolucency respectively. Bone regeneration and formation wasevidenced in all groups but there was an increase of the mean bonedensity that was statistically significant in group I and III.