Background: Dental caries is the most prevalent disease worldwide; affecting nearly 100 % of the population in the majority of countries. It’s one of the greatest challenges to the integrity of the developing tooth; as it progressively damages dental tissues resulting in pulpal damage, and arrest in the development of the tooth root, and subsequent tooth loss and dysfunction. Trial registration: ClinicalTrials.gov (no. NCT02930135). Methods: Randomized, clinical trial to evaluate the clinical and radiographic success of indirect pulp capping of vital young permanent teeth with deep caries using two-step antibacterial bonding system versus conventional one. This study was carried out on thirty sex children. Their age ranged from 7 to 13 years. They were divided in two groups; one group had “One step” indirect pulp capping using antibacterial bonding, another one had the same treatment but with conventional bonding. Clinical and radiographic follow up was carried out immediate postoperative, two, six and nine months. All children were examined clinically for postoperative pain, pain on percussion, presence of swelling, sinus. And radiographically by presence of any adverse radiographic findings and measurement of newly formed dentin thickness. Results: By statistical analysis it was found that both groups were comparable in postoperative pain (p=1.000). And regarding the newly formed dentin thickness; after two months there was a significant difference between two groups (p=0.029), and after 9 months there was not statistically significant difference between two groups (p=0.207). Conclusion: The “One step” indirect pulp capping technique has considerable clinical and radiographic success over 9 months follow up. Antibacterial bonding system provides an early effect on healing power of the pulp in comparison to conventional type. Still the perfect seal regardless of capping material is the key of success in case of indirect pulp capping. After 9 months follow up there wasn’t statistically significant difference between two groups.