The highest values of cholesterol, LDL and TG were recorded in patients with CLI as well as the high risk ratios (cholesterol/HDL, LDL/HDL), while lowest values of HDL were recorded in patients with CLI. The commonest complication of atherosclerotic disease is arterial thromboembolism and excess platelet activation plays a role in the progression of the atherosclerotic disease. This study proved that levels of CD62 and CD63 were the highest in patients with CLI followed by claudication group and lowest values were recorded among control group. Among each group, the values of CD63 were higher than those of CD62. Both indices were highly correlated to each other. As CD62 is an established predictor of cardiovascular ischemic events, CD63 can be used also for the same purpose. Both indices were elevated in diabetic and non diabetic groups with slight insignificant elevation in the non diabetic group. This leaves a question if we can depend on such indices to predict the severity of PAD among diabetics instead of ABI which is unreliable in this situation. This may need many studies over a larger scale of patients to reply this important question. In conclusion, increased PMPs and p-selectin are both related to the severity of symptomatic PAD. However, it is uncertain if this relationship is a cause or effect of atherosclerosis. This may have a clinical implication as PMPs may have the potential to influence the progression of atheroma as well as promote thrombosis.