Background : The superficial femoral artery (SFA) extending to the proximal popliteal artery segment is the most commonly diseased vasculature. More than 50% of all peripheral artery disease (PAD) cases involve the SFA and popliteal artery. Catheter-based interventions serve as a first line intervention for many patients with infrainguinal occlusive disease. Angioplasty with or without stenting offers the advantage of low morbidity, decreased convalescence, and high patient acceptance. Some have suggested that primary nitinol stenting of the superficial and popliteal arteries can provide results that are superior to angioplasty and selective stenting alone and extend the anatomic indications for endovascular intervention. Aim of the study: This study aimed at comparing the short (immediately, after one month) and long term (after 6 months) results of balloon angioplasty alone versus balloon angioplasty and stenting of multiple tandem lesions in superficial femoral and popliteal artery (femoropopliteal occlusive disease). We will also assess the efficacy and durability of primary stenting of the superficial femoral and popliteal artery. Primary patency was chosen as our primary outcome measure as it is the variable least likely to be operator dependent. Patients and methods: This is a prospective study conducted on 40 patients presenting to the vascular and endovascular department in Kasr Al Aini Hospital, Cairo University, between October 2011 and February 2013. For whom percutaneous transluminal angioplasty with dilatation only was done for 20 cases and percutaneous transluminal angioplasty with dilatation and stenting was done for 20 cases. All patients presenting with femoropopliteal occlusive disease with multiple tandem superficial femoral and popliteal arteries lesions (stenosis or occlusion) each less than 5cm. Patient gender, demographics, presence of co-morbidities, history of smoking, indication for intervention and the use of anticoagulation therapy was recorded. In our study, risk factors were examined as predictors of success including age, sex, diabetes, hypertension, smoking history and coronary artery disease. Result: The age of the patients ranged from 41 to 75 years with a mean age of 61.85±9.79 year. Most of the patients age between 61&70 years, they included male being 55% while female were 45 %, all patients (100%) had diabetes, 34 patients (85%) had hypertension (mean BP 152.60±21.57mmHg), and 16 patients (40%) cardiac, while 20 patients (50%) had hyperlipidemia .On stratifying our cases according to TASC lesion type and showed that in group1 11 B (55%) and 9 C (45%), while in group2 9 B (45%) and 11 C (55%) lesions of the SFA.In our study we found that the presence of multiple level lesions (stenosis and occlusion) showed less patency and salvage rate (p value 0.002 and 0.04 respectively). At one month follow up we found in group1 (dilatation):3(three) unsuccessful cases with failure while in group 2, all cases are successful. At six month follow up we found in group1 (dilatation): 10 (ten) unsuccessful cases with failure while in group 2, 11 cases are unsuccessful. There was no significance difference between both groups with p<0.53. Conclusion: Endovascular treatment is the 1st choice of revascularization in CLI with high technical success rate and lower mortality. We conclude that primary stenting of the SFA and popliteal arteries provide durable results in patients with TASC B and TASC C lesions& may be an effective treatment strategy. Based on the results in this series, the use of primary stenting does not extend the anatomic limits of the current treatment.