Coronary artery disease is a major cause of death worldwide. It is expected that the rate of CAD will accelerate the next decade; this may be contributed to increased incidence of aging, obesity, DM, hypertension, dyslipidemia, physical activity, smoking and obesity as well as non-modifiable factors including age, gender, family history and metabolic syndrome. CAD includes wide spectrum that is to say stable angina pectoris, unstable angina, non-ST segment elevation myocardial infarction and ST segment elevation myocardial infarction. The last three categories are included under the title of acute coronary syndrome. 75 patients were compared to 25 controls at their adiponectin level. Patients had lower adiponectin levels compared to controls adiponectin level. The observation that adiponectin was lower among patients with AMI in present study may indicate that this cytokine may be directly involved in the pathophysiology of atherogenesis. It has been found that adiponectin has an anti-atherogenic, anti-inflammatory, antioxidant, and anti-apoptotic effects.