Patients with chronic liver disease may have thyroiditis, hyperthyroidism, or hypothyroidism (Richard, 2008). These facts encouraged us to study the relation between various chronic liver diseases and the thyroid functions. Our study included 80 subjects classified into 4 groups : group (A) included 20 patients with liver cirrhosis due to chronic hepatitis C, group (B) included 20 patients with liver cirrhosis due to other causes than hepatitis C, group (C) included 20 patients with fatty liver, and group (D) included 20 healthy controls. Liver function tests, hepatitis markers, thyroid functions (FT3, FT4, TSH), anti-thyroid peroxidase antibodies(anti-TPO), anti-thyroglobulin antibodies (anti-Tg), liver and thyroid ultrasound were done. We found significant decrease in the FT3 and FT4 in patients with chronic hepatitis C and patients with liver cirrhosis due to other causes compared to patients with fatty liver and the control group. We also found significant increase in the TSH levels in patients with chronic hepatitis C and these findings significantly correlated with disease severity. We found statistically significant increase in anti-TPO and anti-Tg in patients in chronic hepatitis C patients when compared to patients in the other groups.