Diabetes mellitus with pregnancy causes increased mortality and morbidity to both the mother and her offspring. The aim of this study is to investigate the effect of maternal diabetes on some hematological and biochemical parameters of their newborn infants. The study population consisted of 60 neonates divided into 3 groups each consists of 20 neonates group i control group . group ii infants of diabetic mothers with pregetational diabetes and groups iii infants of diabetic mothers with gestational diabetes.Routine investigations were performed for these neonates in the form of measuring serum glucose calcium total and direct bilirubin levels complete blood count and arterial blood gas analysis measurements were performed once for control group just after birth and twice for infants of diabetic mothers idms on admission and jast before discharge from neonatal intensive care unit nicu.Some of the measured variables are affected in idms while others showed no significant difference as compared to control and the reversibility of the affected variables to normal level were not the same on discharge from nicu.