Polycystic ovary syndrome is one of the most common diseases affection women in child bearing period, its consequences range from subtle cosmetic problems as acne and hirsutism to the most detrimental as metabolic syndrome and higher susceptibility to develop diabetes mellitus, this study aimed at elucidating the correlation between gly972arg and ala512pro polymorphisms of the IRS-1 gene and their relation to PCOS. The gly972arg was found to confer positive relative risk to PCOS, while the ala512pro was not encountered in any of the subjects of this study, confirming its rarity in women of Caucasian descent.