Evidence indicated that hypertension is a major contributor to the development of end-stage renal disease. This work was designed to compare the role of the antihypertensive drugs Lacidipine and Hydralazine in reducing the renal cortical damage caused by high fructose diet (HFD) in rats. Materials and methods : Thirty five rats were divided into 5 control and 30 experimental rats. The control rats were maintained on a daily meal composed of bread and milk. The other 30 experimental rats received (HFD) for one month, then all animals were subdivided again into 4 groups : Group A (control group) included 5 rats and were maintained on a daily meal composed of bread and milk for a second month. Group B included 10 rats and continued receiving HFD alone for a second month. Group C included 10 rats and continued receiving HFD and oral Lacidipine 3mg/kg per day during the second month. Group D included 10 rats and continued receiving HFD and Hydralazine 10mg/kg per day injected intraperitoneal during the second month. At the end of the second month all animals were sacrificed. Renal specimens were processed and stained by H and E, Masson's trichrome, PAS reaction and immunohistochemistry using antifibronectin antibody. Morphometric measurements and statistical analysis were also done. Results: Renal cortical sections of the rats fed with HFD (group B) revealed a significant increase in the corpuscular and glomerular diameter compared to the control group (group A). There was also a significant increase in the collagen deposition, significant distortion of the brush border and significant thickening of the basement membrane of the tubules. There was also a significant deposition in the fibronectin. Sections in the rats which received Lacidipine (group C) showed significant decrease in the corpuscular and glomerular diameter compared to group B. There was also a significant decrease in the collagen deposition, significant improvement of the brush border and basement membrane of the tubules compared to group B. There was also a significant reduction in the fibronectin compared to group B, while renal cortical sections in the rats receiving Hydralazine (group D) showed insignificant improvement in the mentioned parameters compared to group B, despite both Lacidipine and Hydralazine were effective in reducing the blood pressure induced by HFD. Conclusion: Lacidipine is effective in reducing target organ damage induced by HFD (The experimental model of hypertension).