Choroidal neovascular membrane (CNVM) is a major cause of visual loss in a variety of macular disorders. Many conditions, known as non-age related macular degeneration, are also associated with choroidal neovascular membrane. These conditions included pathologic myopia, ocular histoplasmosis syndrome (OHS), angioid streaks, multifocal choroiditis, idiopathic choroidal neovascularization, traumatic choroidal rupture and heavy focal laser. The poor visual results following laser photocoagulation in subfoveal choroidal neovascularization have prompted the search for alternative treatments.