The present work constitutes a prospective study on a total number of 92 individuals; 69 patients infected with S. mansoni, 13 with other parasitic infections and 10 normal individuals. The studied individuals were categorized into 4 main groups: Group I, active intestinal schistosomiasis, group II cases with past history of intestinal schistosomiasis, group III (Parasitic control group) and group IV (healthy control group). Results of the current study indicate that PCR using patient's serum can detect circulating DNA of S. mansoni in 96.4% of active intestinal schistosomiasis.