Background: The purpose of this study was to assess the effect of equine BMP (equine lyophilized extracellular matrix bone proteins) in reconstruction of cystic jaw defects. Patients & method: Twelve adult patients (3 males and 9 females) of an average age 20-40 years. Sufferings from cystic lesions of the jaws (mainly radicular), were included in this study. The patients were divided randomly into two groups: Group A (study group) comprised six patients, where the bony defects were filled with demineralized lyophilized equine bone matrix following enucleation of the cystic lesions. Group B act as a control group comprised six patients, in which the cystic defects were allowed to be healed spontaneously, after enucleation of the cystic lesions, without application of any grafts. Results: Clinical post-operative evaluation, all patients were reviewed regarding the surgical site healing was uneventful. The comparison between bone density measurements in the two groups, there was no statistically significant difference between mean bone density measurements in the two groups, at base line and after 3 months; while after 6 months; study group showed statistically significantly higher mean bone density than control group. Conclusion: The present study has shown that the use of demineralized lyophilized equine bone matrix in the treatment of patients with peri-radicular cystic defects was promising as an osteo-inductive graft.