Objectives: the aim of this study was to evaluate the effect of Facemask Therapy Supported on Mini-Screws in Treatment of Skeletal Class III Malocclusion.Materials and methods: The sample of this study consisted of 20 patients. Age ranged from 7.4 to 8.6 years with mean age 8.2 years that was divided into two groups. The patients in Group I underwent maxillary protraction by facemask (reverse pull head gear) supported on C-implant. The patients in Group II underwent maxillary protraction by facemask(Reverse pull head gear) supported on removable acrylic plate.Cone beam computerized tomography images were taken to allow for cephalometric analysis as well as 3 d superimposition.Results: for Mini-screw group there was a statistically significant increase in mean A to N FH (mm), Mandibular length (mm), mid-facial length (mm) and Overjet (mm) posttreatment. There was no statistically significant change in mean Overbite (mm) posttreatment.For Acrylic plate group there was a statistically significant increase in mean A to N FH (mm), Mandibular length (mm), mid-facial length (mm) and Overjet (mm) posttreatment. There was no statistically significant change in mean Overbite (mm) posttreatment. Conclusion: Skeletally anchored facemask is a valid method for protraction of themaxillary appliance for patients requiring a true skeletal improvement. Mini-implants can be used as a rigid anchorage during extra oral protraction. Skeletally anchored facemask can offer a treatment alternative to conventional facemask therapy. The appliance produced better results of skeletal expansion with less Dental effects than conventional appliance.