There are few finite element studies in the literature on the behaviour of masonry-infilled steel frames under cyclic loading, and most of them established complicated three-dimensional models. In this paper, a simplified finite element two-dimensional shell model of masonry-infilled steel frames under cyclic loading was developed. Element types and material constitutive model of cyclic plasticity were described. To simulate the actual behaviour of these frames, the interactions between the frame and the infill panel were accurately modelled. The proposed model was compared with previously proposed by another researcher three-dimensional solid model, then the two models were verified by typical quasi-static test results for infilled steel frames. The suggested model proved its capability for predicting the actual behaviour and failure modes of steel frames with masonry infills. In terms of CPU time, the two-dimensional shell model is greatly more effective than the three-dimensional solid one.