There exist a variety of techniques which can be utilized in seismic-resistant structures in order to protect it from earthquake ground motions. One of these techniques is the employment of vertical eccentrically braced frames (V-EBFs) which dissipate energy during seismic hazard by means of yielding of certain elements, commonly referred to as vertical shear links (VSLs), whereas the whole structures is kept safe in the elastic stage. This paper presents a numerical study on 2-D framed buildings equipped with V-EBFs using two finite element software ANSYS Workbench and ETABS. Each of modal analyses, nonlinear static pushover analyses and nonlinear time history analyses have been conducted on 6 different 2-D framed steel buildings configurations equipped with VSLs made of different metallic alloys, particularly magnesium and steel. Also, how the number of V-EBFs in the building and its placement position influence both the global and local behavior of the buildings have been investigated. Finally, general remarks regarding the optimum conditions of equipping V-EBFs in 2-D framed steel buildings have been pointed out (e.g., VSL material of fabrication, V-EBFs number and placement position).