Pile foundations are slender structural elements and highly recommended as a load transferring system underneath superstructures with a high performance. Pile bearing capacity and associated settlement play a key role in the design of pile foundation. In this research, the details of the experimental work of investigating the effect of pile cross-section configuration on the axial load capacity of a single pile in sand are presented. Model piles with different cross sections are installed in sand using jacking technique method. The effect of the sand relative density (Dr) and the effective pile length ratio (Leff/D) are discussed. A testing program comprised of three model pipe piles with different cross sections as open-ended, closed-ended and conical cross-sectional base at the tip of open-ended pipe piles. Three model pipe piles with the same diameter of 20mm and effective length of (200 and 600mm) are used as model tested piles. The results showed that, the closed-ended pipe pile is the optimum cross section under the same pile geometry and soil conditions. Moreover, conical cross-sectional base pipe pile has more resistance compared with open-ended pipe pile for all tests. Also, it is found that, the axial pile capacity is highly affected by increasing the sand relative density. The results indicated also that, the ultimate axial compression load of long/flexible piles in the case of loose sand has reached (3.25, 2.78 and 2.71) times the ultimate axial load of short/rigid piles for the three cases of closed-ended, open-ended and conical base pipe piles respectively. While, this ratio was found to be (1.23, 1.18 and 1.11) and (1.62, 1.64 and1.93) for the two cases of medium dense and dense sand respectively.