High performance concrete (HPC) is widely used in mega structures and high-rise buildings, especially in the elements that are subjected to high compressive stresses. The main objective of this research is to study the behavior of high performance concrete columns when subjected to eccentric compression loads. An experimental program was prepared to test thirteen square columns till failure. The test parameters are type of the concrete (normal strength concrete, high strength concrete and high performance concrete), longitudinal reinforcement ratio, and eccentricity-to-section width (e/t) ratio. In addition, the efficiency of strengthening eccentric columns using near surface mounted CFRP strips (NSM) and confinement condition with spiral CFRP sheets wrapping are also investigated. The experimental results showed that HPC columns had higher load capacities and ductility compared with normal and high strength concrete columns especially for small eccentricity. The prediction of columns' ultimate loads and moment capacities using interaction diagram based on the Egyptian code gave good agreement with most of the experimental results for steel reinforcement ratio up to 2%, however overestimated the column capacities for higher longitudinal reinforcement ratio.