Excessive damage to numerous pile-supported structures has been observed in many earthquakes as a result of liquefaction-induced lateral spreading. This complex pile-soil system has many inherent uncertainties involved in the system-related variables such as; the liquefaction scenario, lateral soil shift as well as the analysis approximation. Therefore, the objective of the present paper is to extract a quick estimate of the probability of failure of pile under lateral spread of two-layer soil profile. To meet this objective the limit equilibrium based finite element model is integrated with the response surface method as well as the first or second order reliability method. The assumptions of limit equilibrium method are simply applied to a three dimensional (3D) finite element model. The finite element model represents the soil by 3D solid elastoplastic (Drucker-Prager failure criterion) while the pile is represented by elastic 3D beam element. The method is verified, implemented and elaborated with the help of three examples. The risk is computed for both serviceability and ultimate limit state. The superiority of the method lies in its ability to compare the safety of two different soil-pile system in short time. For the considered example, it has been found that soil pressure and pile radius have large sensitivities.