Masonry infill panels are widely used as interior and exterior partition walls for aesthetic reasons and functional needs. In this paper, the structural behavior of 1620 low rise reinforced concrete frames with brick masonry infill for various parameters have been studied using nonlinear pushover analysis to evaluate their influences on strength and deformation patterns. The approach has been used to explore the effects of imposing different masonry infill distributions throughout typical internal and external frames of two bays with three, four and five stories for one of the typical models of school buildings in Egypt. A numerical procedure for the nonlinear analysis of infilled frames based on the finite element method was used. The high degree of material nonlinearity of the infilled RC frames was considered taking into account yielding of steel reinforcement together with cracking, crushing and nonlinear stressstrain relations of wall panel and concrete. Nonlinear macro-analysis was found to be a viable tool for investigating the behavior of infilled RC frame. The results indicated that determination of the transition from low-rise to medium-rise building significantly affected the maximum base shear alteration. It was emphasized that to utilize the infill contribution, bare frames should be adequately designed and proportioned to avoid premature failure mechanisms. Ductility demands should be specified in priora because this might be a limiting factor in pushover analysis. Exterior frames exhibited less stiffer response compared with interior frames. Infill contributions to the maximum base shears increased with their positioning in longer span and ground floor thus eliminated soft-story mechanisms and provided significant stiffness enhancements. Concrete grade and the relative wall to concrete strength along with the wall thickness considerably influenced the relative bare frame to the infill wall base shear contributions. The simpler equivalent static lateral load (ESLL) might be employed for analysis of low rise infilled frames but in conjunction with rigorous notions of continuous damage mechanics. Monitoring frames' stiffness degradation allowed for damage variable identification and enabled expressing frequency attenuation coefficient