Confined masonry is considered one of the popular forms of low-cost, low-rise constructions throughout the world; including the Middle East, South and Central America, Mexico, SouthEast Asia, and South-Eastern Europe. The system relies on a load-bearing wall encased by small cast-in-place reinforced concrete tie columns and tie beams. The distinguishing feature of confined masonry construction is that the masonry wall is constructed prior to the casting of the confining elements, tie columns and tie beams, thus both elements respond integrally when subjected to lateral loads in addition to the cost reduction of the formwork. Since 2010, an extensive research program, aiming at developing structurally and economically efficient hybrid building system for developing countries in general and for Egypt in particular, is being undertaken at the Department of Structural Engineering of Ain Shams University. This paper summarizes the findings of the experimental and analytical phases of this research program on wall assemblies designed and built using locally available materials and with common workmanship and construction practices. The paper presents the confined masonry system as a viable alternative for regular reinforced concrete skeletal buildings for low-cost housing in the developing areas throughout Egypt.