Oxidative stress is involved in many diseases including aging (Liguori I et al., 2018), diabetes, cancer (Yaribeygi H, 2020) and certain infections, particularly by the RNA viruses; a family of corona viruses (Zhang Z et al., 2019). Corona viruses are encapsulated RNA viruses with different types: the classic coronaviruses, responsible for moderate respiratory infections in general, the SARS-CoV and MERS-CoV involved in epidemics of more severe respiratory infections (FMPMC-PS, 2020) and the new coronavirus (SARSCoV2) discovered in January 2020 the causative agent of an infectious disease called COVID-19 which is currently experiencing a worldwide outbreak (Public Health France, 2020). Generally, viral infections lead to an increase in the production of free radicals and a depletion of antioxidants and as a result, oxidative stresses will be accumulated inside the body (Camini FC et al., 2017). Based on the complex pathophysiology of this viral infection (COVID-19), the use of antioxidants must be taken in consideration during the treatment process (Marie-Pierrette Ntyonga-Pono, 2020). This study includes a survey on some Egyptian medicinal plants (those have strong antioxidant activities), in addition to the use of green biotechnologies in the production of important antioxidants from these plants, to be suggested to be used during the treatment of COVID-19. The production of these phytochemicals is often low and depends greatly on the physiological and developmental stages of the plant life. Applicable methods used for the enhancement of the in vitro production of these important antioxidants will be discussed also in this review article (Alam, E., 2020).