Liver diseases impose a substantial global health problem. Female hormones play a crucial role in protection against chronic inflammatory diseases. Estrogen beneficial activities are mediated in the liver via estrogen receptors. Panax ginseng exhibits numerous beneficial therapeutic properties. Fifty rats were randomly allocated into five groups (n=10). Group I included sham-operated rats. The remaining 4 groups underwent ovariectomy at the beginning of the experiment. Rats in group II received only saline starting 6 weeks after the ovariectomy and served as ovariectomy-control group. Groups III, IV & V received thioacetamide (TAA; 300 mg; i.p.) to induce hepatic injury 6 weeks after ovariectomy. Group III received saline; starting the next day after TAA administration and served as TAA-control group. Groups IV & V received panax ginseng (100 and 300 mg/kg/day, p.o.) respectively for 6 weeks; starting the next day after TAA administration. Rats of all groups were investigated for liver function tests as well as total antioxidant capacity (TAC) and advanced glycation end products (AGEs). Histopathological examination of liver tissues was also performed. TAA resulted in significant liver damage. Liver function tests were non-significantly elevated in ovariectomized rats when compared to sham-operated rats. Panax ginseng significantly improved the deteriorated liver function tests as well as serum TAC and AGEs when compared to ovariectomy-control group. It also improved the histopathological picture of liver tissue. The study suggests that panax ginseng potentially mitigates TAA-induced liver injury in ovariectomized rats via modulation of liver function, inflammation as well as oxidative stress in rats.