Background: Depression is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide (Dwyer et al., 2020). Aim: Assess social problem solving among depressed patients. Subjects and Method: The study was carried out using a descriptive research design on a convenience sample of 65 patients diagnosed with depression at the Inpatient and Out-patient Psychiatric Department of Mansoura University Hospital. The two tools used were sociodemographic and Social Problem-Solving Inventory. Results: Result of the current study revealed that 55.4% of the total sample was at the age group between 30-45 years, 61.5% of the patients in the present study were female and 78.5% have insufficient income, 67.7% of sample are from rural area and 66.4% of sample are single. Total score of social problem-solving more than three quarter (80%) of patients demonstrate poor social problem solving. Conclusion: depressed patient has poor social problem-solving ability; so, it is recommended to improve social problem solving while caring for patients with depression.