Renal cell carcinoma (RCC) is the most common type of urogenital cancer. It has a mortality rate of 30- 40% and is more commonly seen in men than women. Cluster of differentiation (CD)24 is a small, highly glycosylated cell adhesion protein that is normally expressed by immune cells as well as epithelial, neural, and muscle cells. Tumor CD24 expression had been linked with alterations in several oncogenic signaling pathways. The aim of our work to evaluate the immunohistochemical expression of CD24 in RCC and detect its relationship with other clinicopathological parameters. Thirty-nine (39) cases (97.5%) showed positive CD24 expression while single case (2.5%) was negative. Score 0 was seen in this single case (2.5%), score +1 was seen in 18 cases (45%), score +2 in 16 cases (40%) and score +3 was seen in 5 cases (12.5%). High CD24 expression had been presented in (52.5%) of cases. There was no significant correlation between CD24 expression and other clinicopathological parameters such as age, gender, histological subtype, tumor grade, pathological tumor stage, lymph node status, capsular invasion, tumor necrosis and lymphovascular emboli