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425945

Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review

Article

Last updated: 11 May 2025

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Tags

Basic and applied research of Chemistry,

Abstract

Gemifloxacin mesylate (GMF) is a fourth generation fluoroquinolone antibacterial synthetic broad-spectrum agent for oral administration with enhanced affinity for bacterial topoisomerase IV and is being developed for the treatment of respiratory and urinary tract infections. The compound has a broad spectrum of activity against Gram-positive and Gram-negative bacteria. There are different analytical methods available to determine GMF applied in quality control of this medicine in order to ensure its effectiveness and safety. A large number of methodologies including UV-visible spectrophotometry, spectrofluorimetry, high performance liquid chromatography, electrochemical and capillary electrophoresis methods have been developed for the quantitation of GMF in bulk, pharmaceutical, and biological samples. UV-spectrophotometric methods lacked wide linear dynamic ranges and sensitivity. There is some scope for developing methods based on ion-association reactions using many acidic anionic dyes, charge-transfer complexation reactions using substituted p-benzoquinone, polynitro phenols, nitro derivatives, etc., and oxidative coupling reactions involving 3-methyl-2-benzo thiazolinone hydrazone and oxidants like cerium(IV), iron(III), permanganate etc.. This paper will attempt to review several published methodologies and the instrumental conditions, which have been applied to measure GMF and within the last 17 years.

DOI

10.21608/bfszu.2024.296119.1397

Keywords

Gemifloxacin mesylate, analytical methods, spectroscopy, HPLC, electrochemical and capillary electrophoresis

Authors

First Name

Ayman

Last Name

Gouda

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Email

aymangouda77@gmail.com

City

Zagazig

Orcid

-

First Name

Ragaa

Last Name

elsheikh

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

ragaaelsheikh@hotmail.com

City

-

Orcid

-

First Name

Moataz

Last Name

Mahmoud

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

mezooom53@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

Abdel Allem

MiddleName

F

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

af2401024@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El Sayed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

a7medzekei@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Ghazy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

dr.ahm.ghazy@gmail.com

City

-

Orcid

-

First Name

Sameh

Last Name

Abdalla

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

sameh7efny@gmail.com

City

-

Orcid

-

First Name

Nessma

Last Name

Jumaa

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

nessmagomaa521@gmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Elsaify

MiddleName

E.M.

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

nohaelsaife@gmail.com

City

Zagazig

Orcid

-

First Name

Nehal

Last Name

Soliman

MiddleName

S.A.

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Email

nehalahmedwatten20@gmail.com

City

Zagazig

Orcid

-

Volume

2025

Article Issue

1

Related Issue

55524

Issue Date

2025-04-01

Receive Date

2024-06-08

Publish Date

2025-04-01

Page Start

86

Page End

101

Print ISSN

1110-1555

Online ISSN

3062-5416

Article File

BFSZU_Volume 2025_Issue 1_Pages 86-101.pdf

PDF . 989.3kB

Link

https://bfszu.journals.ekb.eg/article_425945.html

Detail API

http://journals.ekb.eg?_action=service&article_code=425945

Order

42

Type

Original Article

Type Code

838

Publication Type

Journal

Publication Title

Bulletin of Faculty of Science, Zagazig University

Publication Link

https://bfszu.journals.ekb.eg/

MainTitle

Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review

Details

Type

Article

Created At

11 May 2025