Melanin pigments are found in a wide variety of creatures in nature, including human, microorgasmis and plants.Potential uses for human health exist in the breakdown of melanin. For instance, by degrading melanin to make tumours sensitive to radiation therapy, it might improve the treatment of melanoma. The oxidation of tyrosine produces indoles and other intermediate intermediates, which are present in the irregular light-absorbing polymer known as melanin, Melanin granules, the primary pigment of hair and epidermis, are transported from melanocytes to epithelial cells. There are numerous biological uses for melanin. Melanins are biological macromolecules that are dark, typically black, and made up of different phenolic or indolic monomers. They are frequently complex with proteins and carbohydrates. Animals, plants, protozoans, and microorganisms all make melanin. These studies highlighted the urgent need for a thorough Paper on the melanin pigment isolated from microorganisms. This paper covering biosynthesis, bioproduction, characterization, and potential applications would aid researchers from various backgrounds in comprehending the significance of microbial melanins and in using the information for planning melanin-related studies. With this objective in mind, the current research contrasts traditional and cutting-edge concepts for environmentally sustainable melanin extraction techniques.