Background: Quality of life is usually a cornerstone in patients diagnosed with any chronic disease and its impairment may necessitate some modifications in the management plan. Immune thrombocytopenia (ITP) is a common blood disorder that in most adult cases becomes a chronic disorder. The aim of the work: to explore the effect of ITP on QOL of adult patients with emphasis on different factors that may affect QOL in ITP patients. Methodology: Two hundred subjects were involved in this study, including 100 adult ITP cases in comparison to 100 sex and age matched control. All of them were subjected to structured interview to take detailed data about the disease and treatment plan after that they fulfill the WHOQOL-BREF. Lastly a Blood sample was taken for laboratory investigation. Results: There is a highly significant difference in QOL of ITP patients in comparison to control (p=0.0001). The main impairment was found in chronic ITP patients when compared with acute or persistent patients. There is no difference between cases according to disease type. There is a positive correlation between QOL and platelet count and hemoglobin level while there is negative correlation with total leucocytic count, ITP bleeding score, number of treatment line used and splenoectomy. Conclusion: QOL in ITP patients is affected by several factors that all need to be addressed and modified in order to reach the main goal in ITP treatment to live a relatively normal life.